Plague, a flea-borne zoonosis, is caused by Yersinia pestis and is mainly associated with rodents. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. Survival rate and antibody immune responses were analyzed. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. The rat is assumed to die shortly after infection inducing migration of the fleas. In Madagascar, plague ( Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |